There are historic sites around every corner in the regional capital, Murcia City, and the nearby Roman city of Cartagena, plus both towns are compact enough to walk around. Murcia City was founded by the Arabs in AD 831, and you can still see remnants of the city walls in places. Visit the impressive Gothic, Renaissance and Baroque cathedral, which was started in the 14th century, and numerous churches. Pop your head into the ornate 19th-century casino and visit the impressive Salzillo Museum.
Cartagena, or Carthage as it was named by the Carthaginians more than 2,500 years ago, is an archaeologist's dream, with ruins such as the Roman Villa and Casa de la Fortuna. Visit the medieval Concepcion Castle atop the hill for spectacular views of the city and port. A cruise out of the harbour, meanwhile, offers a different perspective.
Drive south and visit the less touristy spots of Mazarron, which has an attractive old town, and Aguilas, which is renowned for its dive spots and picturesque scenery.
Or head into the hills to the relaxing thermal spas of Archena or Fortuna, where people have been soaking in the therapeutic mineral waters since Roman times. At Archena, there are even parts of the original Roman aqueducts to prove it.